Specifications
| Target | STAT3 |
| Reactivity | Human, Mouse |
| Applications | WB,ICC, ChIP, |
| MW(Calculated) | -- |
| Host Species | Mouse |
| Isotype | Mouse IgG1, κ |
| Recommended Dilution Ratio | Each lot of this antibody is quality control tested by Western blotting . For Western blotting, the suggested use of this reagent is 0.5 - 1.0 µg per ml (1:500 - 1:1000 dilution). For immunocytochemistry, a concentration of 0.5 μg/ml is recommended. For ChIP applications, the suggested dilution is 1:50 by volume. It is recommended that the reagent be titrated for optimal performance for each application. |
| Formulation | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. Previous lots of this product may have been formulated with 0.1% or 0.05% NaN 3 instead of 0.09% NaN 3 . For further information please contact BioLegend Technical Support or Customer Service . |
| Purification | The antibody was purified by affinity chromatography. |
| Storage | Upon receipt, store undiluted between 2°C and 8°C. |
| Concentration | 0.5 mg/ml |
| Clonality | Monoclonal |
| Clone Number | 13A3-1 |
| Immunogen | KLH conjugated modified synthetic peptide |
| Specificity | STAT3 Phospho Tyr705 |
| Gene Name | -- |
| Other Name | Signal transducer and activator of transcription 3, Acute-phase response factor, APRF, HIES |
| Gene ID | 6774 |
| Cellular Localization | Phospho-Proteins |
| Function | STAT3 is tyrosine phosphorylated by receptor kinases in response to a variety of cytokines and growth factors. It forms homo- or heterodimer with STAT1 when tyrosine is phosphorylated, and then translocates to nucleus, acting as a transcription regulator. It is also essential for the differentiation of TH17 cells, which is involved in autoimmune diseases. |
