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Background：
This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011],
| Target | Synaptophysin |
| Reactivity | Human, Mouse, Rat, Bovine |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Source | |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Purity | |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | ABT533 |
| Immunogen | Synthesized peptide derived from human Synaptophysin AA range: 200-313 |
| Sequence | |
| Specificity | The antibody can specifically recognize human Synaptophysin protein. |
| Gene Name | SYP |
| Protein Name | Major synaptic vesicle protein p38; MRX96; MRXSYP; Syn p38; Synaptophysin; Syp; SYPH; SYPH_HUMAN; SypI |
| Other Name | Major synaptic vesicle protein p38; / MRX96; / MRXSYP; / Syn p38; / Synaptophysin; / Syp; / SYPH; / SYPH_HUMAN; / SypI |
| Species | Human |
| Gene ID-1 | 6855 |
| Uniprot | P08247, |
| Species.1 | Mouse |
| Gene ID-2 | 20977 |
| Uniprot.1 | Q62277, |
| Species.2 | Rat |
| Gene ID-3 | 24804 |
| Uniprot.2 | P07825 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR). [provided by RefSeq, Aug 2011], |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | Pancreas/ Colon |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The calcium-binding activity is thought to be localized in the cytoplasmic tail of the protein.,Function:Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane.,online information:Synaptophysin entry,PTM:Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.,similarity:Belongs to the synaptophysin/synaptobrevin family.,similarity:Contains 1 MARVEL domain.,subunit:Homohexamer or homotetramer.,tissue specificity:Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype., |
| RRID |
