Price range: $268.00 through $328.00
Background:
function:Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form., similarity:Contains 3 UPAR/Ly6 domains., subunit:Monomer (Probable). Interacts with MRC2.,
| Size | 50μL/100μL |
| Target | PLAUR |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | 37kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human U-PAR |
| Specificity | This antibody detects endogenous levels of Human U-PAR |
| Gene Name | PLAUR MO3 UPAR |
| Protein Name | Urokinase plasminogen activator surface receptor (U-PAR) (uPAR) (Monocyte activation antigen Mo3) (CD antigen CD87) |
| Other Name | PLAUR; / MO3; / UPAR; / Urokinase plasminogen activator surface receptor; / U-PAR; / uPAR; / Monocyte activation antigen Mo3; / CD antigen CD87 |
| Species | Human |
| Gene ID | 5329 |
| Uniprot | Q03405, |
| Species.1 | Mouse |
| Gene ID.1 | 18793 |
| Uniprot.1 | P35456, |
| Species.2 | Rat |
| Gene ID.2 | 50692 |
| Uniprot.2 | P49616 |
| Cellular Localization | Cell membrane . Cell projection, invadopodium membrane . Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. .; [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor .; [Isoform 2]: Secreted . |
| Tissue Expression | Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades |
| Research Areas | >>Complement and coagulation cascades; / >>Proteoglycans in cancer |
| Function | protein amino acid lipidation, GPI anchor metabolic process, GPI anchor biosynthetic process, phospholipid metabolic process, glycerophospholipid metabolic process, cell motion, chemotaxis, blood coagulation, hemostasis, behavior,locomotory behavior, lipid biosynthetic process, phospholipid biosynthetic process, response to wounding, attachment of GPI anchor to protein, organophosphate metabolic process, regulation of proteolysis, phosphoinositide metabolic process, regeneration, growth, wound healing, lipoprotein metabolic process, lipoprotein biosynthetic process, tissue regeneration, taxis, skeletal muscle regeneration, glycerolipid biosynthetic process, glycerophospholipid biosynthetic process, glycerolipid metabolic process, phosphoinositide biosynthetic process, developmental growth, coagulation,regulation of body fluid levels, |
