Name: UBE2A/B Polyclonal Antibody
SKU: WP15175
Price: 268 USD
Availability: InStock

UBE2A/B Polyclonal Antibody

Ucallm_WP15175-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP15175-100

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Product details

Background:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

Specifications

Target	UBE2A/B
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	17kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from the C-terminal region of human UBE2A/B.
Sequence
Specificity	UBE2A/B Polyclonal Antibody detects endogenous levels of UBE2A/B protein.
Gene Name	UBE2A/UBE2B
Protein Name	Ubiquitin-conjugating enzyme E2 A/Ubiquitin-conjugating enzyme E2 B
Other Name	UBE2A; / RAD6A; / Ubiquitin-conjugating enzyme E2 A; / RAD6 homolog A; / HR6A; / hHR6A; / Ubiquitin carrier protein A; / Ubiquitin-protein ligase A; / UBE2B; / RAD6B; / Ubiquitin-conjugating enzyme E2 B; / RAD6 homolog B; / HR6B; / hHR6B; / Ubiquitin carrier protein B; / Ubiquitin-conjugating enzyme E2-17 kDa; / Ubiquitin-protein ligase B
Species	Human
Gene ID-1	7320
Uniprot	P49459;P63146,
Species.1
Gene ID-2
Uniprot.1
Species.2	Rat
Gene ID-3	81816
Uniprot.2	P63149
Organism-4
Gene ID-4
SwissProt-4
Background	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Cellular Localization	chromatin,nuclear chromatin,XY body,cytoplasm,cytosol,HULC complex,
Tissue Expression	Lung,Skin,Subthalamic nucleus,Thyroid,
Signaling_pathway	Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
Research Areas	>>Ubiquitin mediated proteolysis
Function	Catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Function:Catalyzes the covalent attachment of ubiquitin to other proteins. Required for postreplication repair of UV-damaged DNA.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with RAD18.,
RRID