Price range: $268.00 through $328.00
Background:
URG4 is upregulated in the presence of hepatitis B virus (HBV)-encoded X antigen (HBxAg) and may contribute to the development of hepatocellular carcinoma by promoting hepatocellular growth and survival (Tufan et al., 2002 [PubMed 12082552]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | URGCP |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 102kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human URGCP AA range: 345-395 |
| Specificity | This antibody detects endogenous levels of URGCP at Human/Mouse |
| Gene Name | URGCP KIAA1507 URG4 |
| Protein Name | URGCP |
| Other Name | |
| Species | Human |
| Gene ID | 55665 |
| Uniprot | Q8TCY9, |
| Species.1 | Mouse |
| Gene ID.1 | 72046 |
| Uniprot.1 | Q5NCI0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei. |
| Tissue Expression | Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.,induction:By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).,sequence Caution:Translation N-terminally extended.,subcellular location:In epithelial cells localized predominantly in the cytoplasm and occasionally in nuclei.,tissue specificity:Strongly expressed in hepatitis B-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines., |
