SKU: WP14953 Categories: ,

USP36 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP14953-100
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Product details

Background:

This gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016],

Specifications

TargetUSP36
ReactivityHuman, Mouse
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)125kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human USP36. AA range:501-550
Sequence
SpecificityUSP36 Polyclonal Antibody detects endogenous levels of USP36 protein.
Gene NameUSP36
Protein NameUbiquitin carboxyl-terminal hydrolase 36
Other NameUSP36; / KIAA1453; / Ubiquitin carboxyl-terminal hydrolase 36; / Deubiquitinating enzyme 36; / Ubiquitin thioesterase 36; / Ubiquitin-specific-processing protease 36
SpeciesHuman
Gene ID-157602
UniprotQ9P275,
Species.1Mouse
Gene ID-2
Uniprot.1B1AQJ2
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of the peptidase C19 or ubiquitin-specific protease family of cysteine proteases. Members of this family remove ubiquitin molecules from polyubiquitinated proteins. The encoded protein may deubiquitinate and stabilize the transcription factor c-Myc, also known as MYC, an important oncoprotein known to be upregulated in most human cancers. The encoded protease may also regulate the activation of autophagy. This gene exhibits elevated expression in some breast and lung cancers. [provided by RefSeq, Mar 2016],
Cellular LocalizationNucleus, nucleolus . Cytoplasm .
Tissue ExpressionBroadly expressed.
Signaling_pathway
Research Areas
FunctionCatalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,tissue specificity:Broadly expressed.,
RRID
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