SKU: WP15007 Categories: ,

v-SNARE Vti1p Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15007-100
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Product details

Background:

function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence., similarity:Belongs to the VTI1 family., subunit:Found in a complex with VAMP8 and STX7 in the liver. Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, STX8 and VAMP8., tissue specificity:Expressed in all tissues examined.,

Specifications

Size50μL/100μL
Targetv-SNARE Vti1p
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)26kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the Internal region of human v-SNARE Vti1p.
Specificityv-SNARE Vti1p Polyclonal Antibody detects endogenous levels of v-SNARE Vti1p protein.
Gene NameVTI1B
Protein NameVesicle transport through interaction with t-SNAREs homolog 1B
Other NameVTI1B; / VTI1; / VTI1L; / VTI1L1; / VTI2; / Vesicle transport through interaction with t-SNAREs homolog 1B; / Vesicle transport v-SNARE protein Vti1-like 1; / Vti1-rp1
SpeciesHuman
Gene ID10490
UniprotQ9UEU0,
Species.1Mouse
Gene ID.1
Uniprot.1O88384,
Species.2Rat
Gene ID.2
Uniprot.2P58200
Cellular LocalizationEarly endosome membrane; Single-pass type IV membrane protein . Late endosome membrane; Single-pass type IV membrane protein . Lysosome membrane . Cytoplasmic granule . Recycling endosome membrane; Single-pass type IV membrane protein .
Tissue ExpressionExpressed in all tissues examined.
Signaling_pathway
Research Areas>>SNARE interactions in vesicular transport
FunctionFunction:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.,similarity:Belongs to the VTI1 family.,subunit:Found in a complex with VAMP8 and STX7 in the liver. Forms a SNARE complex with STX7, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Part of the SNARE core complex containing STX7, STX8 and VAMP8.,tissue specificity:Expressed in all tissues examined.,
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