SKU: WP1930 Categories: ,

VA0D2 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1930-100
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Product details

Background:

function:Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis., similarity:Belongs to the V-ATPase V0D/AC39 subunit family., subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c’, c” and d)., tissue specificity:Kidney, osteoclast and lung.,

Specifications

Size50μL/100μL
TargetVA0D2
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)38kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityVA0D2 Polyclonal Antibody detects endogenous levels of protein.
Gene NameATP6V0D2
Protein NameV-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)
Other Name
SpeciesHuman
Gene ID245972
UniprotQ8N8Y2,
Species.1Mouse
Gene ID.1
Uniprot.1Q80SY3,
Species.2Rat
Gene ID.2
Uniprot.2Q5FVL0
Cellular Localizationlysosomal membrane,early endosome,endosome membrane,membrane,apical plasma membrane,vacuolar proton-transporting V-type ATPase complex,phagocytic vesicle membrane,proton-transporting V-type ATPase, V0 domain,plasma membrane proton-transporting V
Tissue ExpressionKidney, osteoclast and lung.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Immune disease >> Rheumatoid arthritis
Research Areas>>Oxidative phosphorylation; / >>Metabolic pathways; / >>Lysosome; / >>Phagosome; / >>Synaptic vesicle cycle; / >>Collecting duct acid secretion; / >>Vibrio cholerae infection; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Tuberculosis; / >>Human papillomavirus infection; / >>Viral carcinogenesis; / >>Rheumatoid arthritis
FunctionFunction:Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis.,similarity:Belongs to the V-ATPase V0D/AC39 subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).,tissue specificity:Kidney, osteoclast and lung.,
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