Price range: $268.00 through $328.00
Background:
This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol pentakisphosphate to bis-diphosphoinositol tetrakisphosphate. This protein may be important for intracellular signaling pathways. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 15.[provided by RefSeq, Jun 2010],
| Size | 50μL/100μL |
| Target | VIP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 158kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human VIP1 AA range: 1350-1400 |
| Specificity | This antibody detects endogenous levels of VIP1 at Human/Mouse/Rat |
| Gene Name | PPIP5K1 HISPPD2A IP6K IPS1 KIAA0377 VIP1 |
| Protein Name | VIP1 |
| Other Name | |
| Species | Human |
| Gene ID | 9677 |
| Uniprot | Q6PFW1, |
| Species.1 | Mouse |
| Gene ID.1 | 327655 |
| Uniprot.1 | A2ARP1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P0C644 |
| Cellular Localization | Cytoplasm, cytosol . Cell membrane . Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. . |
| Tissue Expression | Widely expressed, with a higher expression in skeletal muscle, heart and brain. |
| Signaling_pathway | |
| Research Areas | >>Phosphatidylinositol signaling system |
| Function | Catalytic activity:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown).,Catalytic activity:ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate = ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown).,Catalytic activity:ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate.,Caution:Although related to histidine acid phosphatases, it lacks the conserved active sites, suggesting that it has no phosphatase activity.,Function:Bifunctional inositol kinase that catalyzes the formation of diphosphoinositol pentakisphosphate (InsP7 or PP-InsP5) and bi-diphosphoinositol tetrakisphosphate (InsP8 or PP2-InsP4). Converts inositolitol hexakisphosphate (InsP6) to InsP7. Also able to convert InsP7 to InsP8. Probably specifically mediates the formation of 4PP-InsP5 and 6PP-InsP5 InsP7 isomers but not of 5PP-IP5 InsP7 isomer. Activated when cells are exposed to hyperosmotic stress.,similarity:Belongs to the histidine acid phosphatase family. VIP1 subfamily.,tissue specificity:Widely expressed, with a higher expression in skeletal muscle, heart and brain., |
