Product details
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VPRBP rabbit pAb
Ucallm_WP4141-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | VPRBP |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 166kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human VPRBP AA range: 804-854 |
| Specificity | This antibody detects endogenous levels of VPRBP at Human/Mouse |
| Gene Name | VPRBP DCAF1 KIAA0800 RIP |
| Protein Name | VPRBP |
| Other Name | |
| Species | Human |
| Gene ID | 9730 |
| Uniprot | Q9Y4B6, |
| Species.1 | Mouse |
| Gene ID.1 | 321006 |
| Uniprot.1 | Q80TR8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis. |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | >>Human immunodeficiency virus 1 infection |
| Function | Domain:Although not canonical, the WD repeat-like region is related to WD repeats.,Function:May act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr, possibly leading to hijack the RBX1-CUL4-DDB2 and arrest the cell cycle in G2 phase.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the VPRBP family.,similarity:Contains 1 LisH domain.,subunit:Interacts with DDB1, suggesting that it may participate to some RBX1-CUL4-DDB2 ubiquitin ligase complex. In case of infection, interacts with HIV-1 virus Vpr protein and forms a ternary complex with HIV-1 Vpr and DDB1.,tissue specificity:Ubiquitously expressed., |
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