Product details
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VPS25 rabbit pAb
Ucallm_WP6324-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | VPS25 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 19kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human VPS25 |
| Specificity | This antibody detects endogenous levels of VPS25 at Human, Mouse,Rat |
| Gene Name | VPS25 DERP9 EAP20 |
| Protein Name | Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25) |
| Other Name | |
| Species | Human |
| Gene ID | 84313 |
| Uniprot | Q9BRG1, |
| Species.1 | Mouse |
| Gene ID.1 | 28084 |
| Uniprot.1 | Q9CQ80, |
| Species.2 | Rat |
| Gene ID.2 | 681059 |
| Uniprot.2 | P0C0A1 |
| Cellular Localization | Cytoplasm. Endosome membrane. Nucleus, nucleoplasm. Distributes diffusely throughout the cytoplasm and nucleoplasm, but exhibits a punctate distribution on coexpression with CHMP6. |
| Tissue Expression | Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. |
| Signaling_pathway | |
| Research Areas | |
| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses. |
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