WAVE2 Polyclonal Antibody
Ucallm_WP15010-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],
Specifications
| Size | 50μL/100μL |
| Target | WAVE2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human WASF2. AA range:141-190 |
| Specificity | WAVE2 Polyclonal Antibody detects endogenous levels of WAVE2 protein. |
| Gene Name | WASF2 |
| Protein Name | Wiskott-Aldrich syndrome protein family member 2 |
| Other Name | WASF2; / WAVE2; / Wiskott-Aldrich syndrome protein family member 2; / WASP family protein member 2; / Protein WAVE-2; / Verprolin homology domain-containing protein 2 |
| Species | Human |
| Gene ID | 10163 |
| Uniprot | Q9Y6W5, |
| Species.1 | Mouse |
| Gene ID.1 | 242687 |
| Uniprot.1 | Q8BH43 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Basolateral cell membrane . At the interface between the lamellipodial actin meshwork and the membrane. . |
| Tissue Expression | Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis |
| Research Areas | >>Adherens junction; / >>Fc gamma R-mediated phagocytosis; / >>Regulation of actin cytoskeleton; / >>Bacterial invasion of epithelial cells; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Yersinia infection; / >>Choline metabolism in cancer |
| Function | Domain:Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.,Function:Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.,similarity:Belongs to the SCAR/WAVE family.,similarity:Contains 1 WH2 domain.,subcellular location:At the interface between the lamellipodial actin meshwork and the membrane.,subunit:Binds actin and the Arp2/3 complex. Interacts with BAIAP2. Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. Directly interacts with C3orf10/HSPC300.,tissue specificity:Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle., |
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