WDR79 Monoclonal Antibody
Ucallm_WM0551-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011],
Specifications
| Size | 50μL/100μL |
| Target | WDR79 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 59kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-1:2000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 17C8 |
| Immunogen | Purified recombinant human WDR79 protein fragments expressed in E.coli. |
| Specificity | WDR79 Monoclonal Antibody detects endogenous levels of WDR79 protein. |
| Gene Name | WRAP53 |
| Protein Name | Telomerase Cajal body protein 1 |
| Other Name | WRAP53; / TCAB1; / WDR79; / Telomerase Cajal body protein 1; / WD repeat-containing protein 79; / WD40 repeat-containing protein encoding RNA antisense to p53 |
| Species | Human |
| Gene ID | 55135 |
| Uniprot | Q9BUR4, |
| Species.1 | Mouse |
| Gene ID.1 | 216853 |
| Uniprot.1 | Q8VC51, |
| Species.2 | Rat |
| Gene ID.2 | 287432 |
| Uniprot.2 | Q5XII5 |
| Cellular Localization | Nucleus, Cajal body . Chromosome, telomere . Chromosome . Released from telomerase RNA template component (TERC) in mitotic cells coincident with delocalization from Cajal bodies (PubMed:26170453). In response to DNA damage, localizes to sites of DNA double-strand breaks following phosphorylation by ATM (PubMed:26734725, PubMed:27715493). . |
| Tissue Expression | Expressed in all tissues and cell lines examined. |
| Signaling_pathway | |
| Research Areas | |
| Function | DNA metabolic process, telomere organization, telomere assembly, telomere formation via telomerase, positive regulation of catalytic activity, positive regulation of molecular function, chromosome organization, regulation of transferase activity, positive regulation of transferase activity, regulation of telomerase activity, positive regulation of telomerase activity, |
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