Product details
Background:
WWP1 rabbit pAb
Ucallm_WP17926-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | WWP1 |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| MW(Calculated) | 101kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human N-ternal WWP1 |
| Specificity | This antibody detects endogenous levels of WWP1 at Human, Mouse |
| Gene Name | WWP1 |
| Protein Name | NEDD4-like E3 ubiquitin-protein ligase WWP1 (Atrophin-1-interacting protein 5) (AIP5) (TGIF-interacting ubiquitin ligase 1) (Tiul1) (WW domain-containing protein 1) |
| Other Name | NEDD4-like E3 ubiquitin-protein ligase WWP1; / Atrophin-1-interacting protein 5; / AIP5; / TGIF-interacting ubiquitin ligase 1; / Tiul1; / WW domain-containing protein 1 |
| Species | Human |
| Gene ID | 11059 |
| Uniprot | Q9H0M0, |
| Species.1 | Mouse |
| Gene ID.1 | 107568 |
| Uniprot.1 | Q8BZZ3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Cell membrane; Peripheral membrane protein . Nucleus . |
| Tissue Expression | Detected in heart, placenta, pancreas, kidney, liver, skeletal muscle, bone marrow, fetal brain, and at much lower levels in adult brain and lung. Isoform 1 and isoform 5 predominate in all tissues tested, except in testis and bone marrow, where isoform 5 is expressed at much higher levels than isoform 1. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF. |
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