Product details
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WWP2 rabbit pAb
Ucallm_WP6313-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | WWP2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 96kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human WWP2 |
| Specificity | This antibody detects endogenous levels of WWP2 at Human, Mouse |
| Gene Name | WWP2 |
| Protein Name | NEDD4-like E3 ubiquitin-protein ligase WWP2 (Atrophin-1-interacting protein 2) (AIP2) (WW domain-containing protein 2) |
| Other Name | |
| Species | Human |
| Gene ID | 11060 |
| Uniprot | O00308, |
| Species.1 | Mouse |
| Gene ID.1 | 66894 |
| Uniprot.1 | Q9DBH0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Detected in heart, throughout the brain, placenta, lung, liver, muscle, kidney and pancreas. Also detected in spleen and peripheral blood leukocytes. |
| Signaling_pathway | Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis |
| Research Areas | |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation. |
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