Product details
Background:
- Please choose product options by visiting VEZA rabbit pAb.
C42S2 rabbit pAb
Ucallm_WP3962-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | C42S2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | 9kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human C42S2 AA range: 3-53 |
| Specificity | This antibody detects endogenous levels of C42S2 at Human/Mouse/Rat |
| Gene Name | CDC42SE2 SPEC2 |
| Protein Name | C42S2 |
| Other Name | |
| Species | Human |
| Gene ID | 56990 |
| Uniprot | Q9NRR3, |
| Species.1 | Mouse |
| Gene ID.1 | 72729 |
| Uniprot.1 | Q8BGH7, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | A1L1K4 |
| Cellular Localization | Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor. Cell projection, phagocytic cup. Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages. |
| Tissue Expression | Widely expressed. Expressed at higher level in T-lymphocytes. Highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The CRIB domain mediates interaction with CDC42.,Function:Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.,miscellaneous:CDC42SE2 is mapped in the genomic region associated with schizophrenia.,similarity:Belongs to the CDC42SE/SPEC family.,similarity:Contains 1 CRIB domain.,subcellular location:Recruited to the activated TCR prior actin polymerization. Localizes at the phagocytic cup of macrophages.,subunit:Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.,tissue specificity:Widely expressed. Expressed at higher level in T lymphocytes. Highly expressed in CCRF-CEM T lymphocytes, Jurkat T lymphocytes, and Raji B lymphocytes compared (at protein level)., |
Please login to post questions
Related products
