Price range: $268.00 through $328.00
Background:
This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009],
| Size | 50μL/100μL |
| Target | XPP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 68kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | XPP1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | XPNPEP1 XPNPEPL XPNPEPL1 |
| Protein Name | Xaa-Pro aminopeptidase 1 (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) |
| Other Name | |
| Species | Human |
| Gene ID | 7511 |
| Uniprot | Q9NQW7, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q6P1B1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | O54975 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.,cofactor:Manganese.,enzyme regulation:Inhibited by apstatin and the metal ion chelators EDTA and 1,10-phenanthroline. Partially inhibited by dithiothreitol. Not inhibited by enalaprilat or amastatin.,similarity:Belongs to the peptidase M24B family.,subunit:Homodimer.,tissue specificity:Expressed in all tissues tested, including pancreas, heart, muscle, kidney, liver, lung and brain. Highest levels in pancreas., |
