SKU: WP17019 Categories: ,

ZMYM3 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP17019-100
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Product details

Background:

This gene is located on the X chromosome and is subject to X inactivation. It is highly conserved in vertebrates and most abundantly expressed in the brain. The encoded protein is a component of histone deacetylase-containing multiprotein complexes that function through modifying chromatin structure to keep genes silent. A chromosomal translocation (X;13) involving this gene is associated with X-linked mental retardation. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2010],

Specifications

Size50μL/100μL
TargetZMYM3
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)151kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ZMYM3 AA range: 258-308
SpecificityThis antibody detects endogenous levels of ZMYM3 at Human/Mouse
Gene NameZMYM3 DXS6673E KIAA0385 ZNF261
Protein NameZMYM3
Other Name
SpeciesHuman
Gene ID9203
UniprotQ14202,
Species.1Mouse
Gene ID.156364
Uniprot.1Q9JLM4
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationNucleus .
Tissue ExpressionMost abundant in brain, moderate in muscle and heart, low in other tissues except placenta.
Signaling_pathway
Research Areas
FunctionDisease:A chromosomal aberration involving ZMYM3 may be a cause of X-linked mental retardation in Xq13.1. Translocation t(X; 13)(q13.1; ?).,similarity:Contains 9 MYM-type zinc fingers.,subunit:May be a component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, AOF2/LSD1, RCOR1/CoREST, PHF21A/BHC80, ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I.,tissue specificity:Most abundant in brain, moderate in muscle and heart, low in other tissues except placenta.,
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