Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human ZWILCH
Specificity
This antibody detects endogenous levels of ZWILCH at Human, Mouse
Gene Name
ZWILCH
Protein Name
Protein zwilch homolog (hZwilch)
Other Name
Species
Human
Gene ID
55055
Uniprot
Q9H900,
Species.1
Mouse
Gene ID.1
68014
Uniprot.1
Q8R060
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Chromosome, centromere, kinetochore .
Tissue Expression
Signaling_pathway
Research Areas
Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex .