Specifications
| Size | 50μL/100μL |
| Target | PAX-5 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, ELISA |
| MW(Calculated) | 42kD |
| MW(Observed) | 42kD |
| Host Species | Mouse |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1332 |
| Immunogen | Synthesized peptide derived from human PAX-5 AA range:300-383 |
| Specificity | This antibody detects endogenous levels of PAX-5 protein. |
| Gene Name | PAX5 |
| Protein Name | PAX-5 |
| Other Name | Paired box protein Pax-5; / B-cell-specific transcription factor; / BSAP |
| Species | Human |
| Gene ID | 5079 |
| Uniprot | Q02548, |
| Species.1 | Mouse |
| Gene ID.1 | 18507 |
| Uniprot.1 | Q02650 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nuclear |
| Tissue Expression | |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer |
| Research Areas | |
| Function | developmental stage:Expressed at early B-cell differentiation, in the developing CNS and in adult testis.,Disease:A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9; 18)(p13; q11.2) with ZNF521. Translocation t(9; 3)(p13; p14.1) with FOXP1. Translocation t(9; 12)(p13; p13) with ETV6.,Function:May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.,PTM:O-glycosylated.,similarity:Contains 1 paired domain.,subunit:Interacts with DAXX (By similarity). Binds DNA as a monomer. Binds TLE4., |
