Price range: $268.00 through $328.00
Background:
This gene encodes an RNA binding protein. The encoded protein is part of the spliceosome complex and functions in the second catalytic step of mRNA splicing. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 9 and 15. [provided by RefSeq, Mar 2009],
| Size | 50μL/100μL |
| Target | SPF45 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 44kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | SPF45 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | RBM17 SPF45 |
| Protein Name | Splicing factor 45 (45 kDa-splicing factor) (RNA-binding motif protein 17) |
| Other Name | |
| Species | Human |
| Gene ID | 84991 |
| Uniprot | Q96I25, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8JZX4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Epithelium,Eye,Liver,Testis,Uterus, |
| Signaling_pathway | |
| Research Areas | >>Spliceosome |
| Function | Function:Splice factor that binds to the single stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. Promotes the utilization of a cryptic splice site created by the beta-110 mutation in the HBB gene. The resulting frameshift leads to sickle cell anemia.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,subunit:Binds SXL. Associates with the spliceosome., |
