Price range: $268.00 through $328.00
Background:
This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016],
| Size | 50μL/100μL |
| Target | Casein Kinase Iγ1/2/3 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 50kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CK-1gamma1/2/3. AA range:229-278 |
| Specificity | Casein Kinase Iγ1/2/3 Polyclonal Antibody detects endogenous levels of Casein Kinase Iγ1/2/3 protein. |
| Gene Name | CSNK1G1/CSNK1G2/CSNK1G3 |
| Protein Name | Casein kinase I isoform gamma-1/2/3 |
| Other Name | CSNK1G1; / Casein kinase I isoform gamma-1; / CKI-gamma 1; / CSNK1G2; / CK1G2; / Casein kinase I isoform gamma-2; / CKI-gamma 2; / CSNK1G3; / Casein kinase I isoform gamma-3; / CKI-gamma 3 |
| Species | Human |
| Gene ID | 53944;1455;1456 |
| Uniprot | Q9HCP0;P78368;Q9Y6M4, |
| Species.1 | Mouse |
| Gene ID.1 | 214897;103236;70425, |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID.2 | 64086;65278;64823 |
| Uniprot.2 | Q62761;Q62762;Q62763 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Brain,Muscle,Pooled, |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway |
| Research Areas | >>Hedgehog signaling pathway |
| Function | Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer., |
