Price range: $268.00 through $328.00
Background:
disease:Defects in RBM6 are found in non-small cell lung cancer (NSCLC) cell lines., function:Specifically binds poly(G) RNA homopolymers in vitro., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 G-patch domain., similarity:Contains 1 RRM (RNA recognition motif) domain., tissue specificity:Ubiquitous in adults.,
| Size | 50μL/100μL |
| Target | DEF3 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 150kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RBM6. AA range:991-1040 |
| Specificity | DEF-3 Polyclonal Antibody detects endogenous levels of DEF-3 protein. |
| Gene Name | RBM6 |
| Protein Name | RNA-binding protein 6 |
| Other Name | RBM6; / DEF3; / RNA-binding protein 6; / Lung cancer antigen NY-LU-12; / Protein G16; / RNA-binding motif protein 6; / RNA-binding protein DEF-3 |
| Species | Human |
| Gene ID | 10180 |
| Uniprot | P78332 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Ubiquitous in adults. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in RBM6 are found in non-small cell lung cancer (NSCLC) cell lines.,Function:Specifically binds poly(G) RNA homopolymers in vitro.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 G-patch domain.,similarity:Contains 1 RRM (RNA recognition motif) domain.,tissue specificity:Ubiquitous in adults., |
