SKU: WP15543 Categories: ,

ALR Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP15543-100
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Product details

Background:

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetALR
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)24kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human GFER. AA range:51-100
SpecificityALR Polyclonal Antibody detects endogenous levels of ALR protein.
Gene NameGFER
Protein NameFAD-linked sulfhydryl oxidase ALR
Other NameGFER; / ALR; / HERV1; / HPO; / FAD-linked sulfhydryl oxidase ALR; / Augmenter of liver regeneration; / hERV1; / Hepatopoietin
SpeciesHuman
Gene ID2671
UniprotP55789,
Species.1Mouse
Gene ID.111692
Uniprot.1P56213,
Species.2Rat
Gene ID.227100
Uniprot.2Q63042
Cellular Localization[Isoform 1]: Mitochondrion intermembrane space. Mitochondrion .; [Isoform 2]: Cytoplasm. Secreted.
Tissue ExpressionUbiquitously expressed. Highest expression in the testis and liver and low expression in the muscle.
Signaling_pathway
Research Areas
FunctionCatalytic activity:4 R'C(R)SH + O(2) = 2 R'C(R)S-S(R)CR' + 2 H(2)O.,cofactor:FAD.,Function:FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation.,similarity:Contains 1 ERV/ALR sulfhydryl oxidase domain.,subunit:Homodimer.,
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