Fas Rabbit Monoclonal antibody

Background：The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells.

Elevate your Fas-mediated apoptosis and cancer pathogenesis research with the highly specific Fas Rabbit Monoclonal Antibody. Validated across diverse cell lines and optimized for Western Blot, it’s the trusted tool for investigating Fas (TNF-receptor superfamily)-driven death-inducing signaling complex (DISC) formation, immune system disease mechanisms, and NF-kappaB signaling pathways. Accelerate discoveries in oncology and immunobiology with this top-tier antibody today!