Name: 14-3-3 γ Polyclonal Antibody
SKU: WP10844
Price: 268 USD
Availability: InStock

14-3-3 γ Polyclonal Antibody

Ucallm_WP10844-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP10844-100

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Product details

Background:

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	14-3-3 γ
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	28kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human 14-3-3 gamma. AA range:51-100
Specificity	14-3-3 γ Polyclonal Antibody detects endogenous levels of 14-3-3 γ protein.
Gene Name	YWHAG
Protein Name	14-3-3 protein gamma
Other Name	YWHAG; / 14-3-3 protein gamma; / Protein kinase C inhibitor protein 1; / KCIP-1
Species	Human
Gene ID	7532
Uniprot	P61981,
Species.1	Mouse
Gene ID.1	22628
Uniprot.1	P61982,
Species.2	Rat
Gene ID.2	56010
Uniprot.2	P61983
Cellular Localization	Cytoplasm .
Tissue Expression	Highly expressed in brain, skeletal muscle, and heart.
Signaling_pathway	Cellular Processes >> Cell growth and death >> Cell cycle;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> PI3K-Akt signaling pathway
Research Areas	>>Cell cycle; / >>Oocyte meiosis; / >>PI3K-Akt signaling pathway; / >>Hippo signaling pathway; / >>Hepatitis C; / >>Viral carcinogenesis
Function	Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,PTM:Phosphorylated by various PKC isozymes.,similarity:Belongs to the 14-3-3 family.,subunit:Homodimer. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm.,tissue specificity:Highly expressed in brain, skeletal muscle, and heart.,

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14-3-3 γ Polyclonal Antibody

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14-3-3 γ Polyclonal Antibody

Product details

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