Price range: $268.00 through $328.00
Background:
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
| Size | 50μL/100μL |
| Target | A Cyclase I |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 130kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ADCY1. AA range:231-280 |
| Specificity | A Cyclase I Polyclonal Antibody detects endogenous levels of A Cyclase I protein. |
| Gene Name | ADCY1 |
| Protein Name | Adenylate cyclase type 1 |
| Other Name | ADCY1; / Adenylate cyclase type 1; / ATP pyrophosphate-lyase 1; / Adenylate cyclase type I; / Adenylyl cyclase 1; / Ca; / 2+; / /calmodulin-activated adenylyl cyclase |
| Species | Human |
| Gene ID | 107 |
| Uniprot | Q08828, |
| Species.1 | Mouse |
| Gene ID.1 | 432530 |
| Uniprot.1 | O88444 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . Cytoplasm . Membrane raft . Expressed in the cytoplasm of supporting cells and hair cells of the cochlea vestibule, as well as to the cochlear hair cell nuclei and stereocilia. . |
| Tissue Expression | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Brain, retina and adrenal medulla. |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Organismal Systems >> Immune system >> Platelet activation;Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> GnRH signaling pathway;Organismal Systems >> Endocrine system >> Estrogen signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Endocrine system >> Growth hormone synthesis, secretion and action;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Cholinergic synapse;Organismal Systems >> Sensory system >> Inflammatory mediator regulation of TRP channels;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Human Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> Phospholipase D signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | >>Purine metabolism; / >>Metabolic pathways; / >>Endocrine resistance; / >>Rap1 signaling pathway; / >>Calcium signaling pathway; / >>cGMP-PKG signaling pathway; / >>cAMP signaling pathway; / >>Chemokine signaling pathway; / >>Phospholipase D signaling pathway; / >>Oocyte meiosis; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Adrenergic signaling in cardiomyocytes; / >>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Gap junction; / >>Platelet activation; / >>Circadian entrainment; / >>Thermogenesis; / >>Long-term potentiation; / >>Retrograde endocannabinoid signaling; / >>Glutamatergic synapse; / >>Cholinergic synapse; / >>GABAergic synapse; / >>Inflammatory mediator regulation of TRP channels; / >>Insulin secretion; / >>GnRH signaling pathway; / >>Ovarian steroidogenesis; / >>Progesterone-mediated oocyte maturation; / >>Estrogen signaling pathway; / >>Melanogenesis; / >>Thyroid hormone synthesis; / >>Oxytocin signaling pathway; / >>Regulation of lipolysis in adipocytes; / >>Aldosterone synthesis and secretion; / >>Relaxin signaling pathway; / >>Cortisol synthesis and secretion; / >>Parathyroid hormone synthesis, secretion and action; / >>Cushing syndrome; / >>Growth hormone synthesis, secretion and action; / >>Salivary secretion; / >>Gastric acid secretion; / >>Pancreatic secretion; / >>Bile secretion; / >>Morphine addiction; / >>Chagas disease; / >>Amoebiasis; / >>Human cytomegalovirus infection; / >>Human T-cell leukemia virus 1 infection; / >>Pathways in cancer; / >>Chemical carcinogenesis - receptor activation; / >>Dilated cardiomyopathy |
| Function | Catalytic activity:ATP = 3',5'-cyclic AMP + diphosphate.,cofactor:Binds 2 magnesium ions per subunit.,enzyme regulation:Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex.,Function:This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning.,similarity:Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.,similarity:Contains 2 guanylate cyclase domains.,tissue specificity:Brain, retina and adrenal medulla., |
