Product details
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ACSL4 rabbit pAb
Ucallm_WP17876-50
Price range: $268.00 through $328.00
Specifications
| Target | ACSL4 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 75kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ACSL4 |
| Sequence | |
| Specificity | This antibody detects endogenous levels of ACSL4 at Human, Mouse,Rat |
| Gene Name | ACSL4 ACS4 FACL4 LACS4 |
| Protein Name | ACSL4 |
| Other Name | Long-chain-fatty-acid--CoA ligase 4; / Long-chain acyl-CoA synthetase 4; / LACS 4 |
| Species | Human |
| Gene ID-1 | 2182 |
| Uniprot | O60488, |
| Species.1 | Mouse |
| Gene ID-2 | 50790 |
| Uniprot.1 | Q9QUJ7, |
| Species.2 | Rat |
| Gene ID-3 | 113976 |
| Uniprot.2 | O35547 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016] |
| Cellular Localization | Mitochondrion outer membrane; Single-pass type III membrane protein . Peroxisome membrane; Single-pass type III membrane protein . Microsome membrane; Single-pass type III membrane protein . Endoplasmic reticulum membrane; Single-pass type III membrane protein . Cell membrane . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>Fatty acid biosynthesis; / >>Fatty acid degradation; / >>Metabolic pathways; / >>Fatty acid metabolism; / >>PPAR signaling pathway; / >>Peroxisome; / >>Ferroptosis; / >>Thermogenesis; / >>Adipocytokine signaling pathway |
| Function | |
| RRID |
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