ALPP/ALPPL2 Polyclonal Antibody
Ucallm_WP15420-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015],
Specifications
| Size | 50μL/100μL |
| Target | PLAP |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human ALPP/ALPPL2. AA range:1-50 |
| Specificity | ALPP/ALPPL2 Polyclonal Antibody detects endogenous levels of ALPP/ALPPL2 protein. |
| Gene Name | ALPP/ALPPL2 |
| Protein Name | Alkaline phosphatase, placental type/Alkaline phosphatase, placental-like |
| Other Name | ALPP; / PLAP; / Alkaline phosphatase, placental type; / Alkaline phosphatase Regan isozyme; / Placental alkaline phosphatase 1; / PLAP-1; / ALPPL2; / ALPPL; / Alkaline phosphatase, placental-likeALP-1; / Alkaline phosphatase Nagao isozyme; / Germ cell alkaline phosphatase; / GCAP; / Placental alkaline phosphatase-like; / PLAP-like |
| Species | Human |
| Gene ID | 250;251 |
| Uniprot | P05187;P10696, |
| Species.1 | Mouse |
| Gene ID.1 | 11650 |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Lipid-anchor, GPI-anchor . |
| Tissue Expression | Detected in placenta (at protein level). |
| Signaling_pathway | |
| Research Areas | >>Thiamine metabolism; / >>Folate biosynthesis; / >>Metabolic pathways; / >>Biosynthesis of cofactors |
| Function | Catalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,miscellaneous:In most mammals there are four different isozymes: placental, placental-like, intestinal and tissue non-specific (liver/bone/kidney).,online information:Alkaline phosphatase entry,polymorphism:Placental ALP is highly polymorphic, there are at least three common alleles.,similarity:Belongs to the alkaline phosphatase family.,subunit:Homodimer., |
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