Price range: $268.00 through $328.00
Background:
This gene encodes a subunit of a heterotetrameric adapter-like complex 4 that is involved in targeting proteins from the trans-Golgi network to the endosomal-lysosomal system. Mutations in this gene are associated with cerebral palsy spastic quadriplegic type 5 (CPSQ5) disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
| Size | 50μL/100μL |
| Target | AP4B1 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 81kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AP4B1 AA range: 595-645 |
| Specificity | This antibody detects endogenous levels of AP4B1 at Human/Mouse |
| Gene Name | AP4B1 |
| Protein Name | AP4B1 |
| Other Name | |
| Species | Human |
| Gene ID | 10717 |
| Uniprot | Q9Y6B7, |
| Species.1 | Mouse |
| Gene ID.1 | 67489 |
| Uniprot.1 | Q9WV76 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | >>Lysosome |
| Function | Function:Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system.,similarity:Belongs to the adaptor complexes large subunit family.,subcellular location:Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells.,subunit:Adapter-like complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1).,tissue specificity:Widely expressed., |
