Price range: $268.00 through $328.00
Background:
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
| Size | 50μL/100μL |
| Target | ARHGEF10 |
| Reactivity | Human, Monkey |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 152kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388 |
| Specificity | ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein. |
| Gene Name | ARHGEF10 |
| Protein Name | Rho guanine nucleotide exchange factor 10 |
| Other Name | ARHGEF10; / KIAA0294; / Rho guanine nucleotide exchange factor 10 |
| Species | Human |
| Gene ID | 9639 |
| Uniprot | O15013, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8C033 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | centrosome,cytosol, |
| Tissue Expression | Amygdala,Brain,Duodenum,Prostate,Testis,Uterus, |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,Function:May play a role in developmental myelination of peripheral nerves.,sequence Caution:Cloning artifact.,sequence Caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain., |
