Arnt 2 Polyclonal Antibody
Ucallm_WP11134-50
Price range: $268.00 through $328.00
Product details
Background:
aryl hydrocarbon receptor nuclear translocator 2(ARNT2) Homo sapiens This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013],
Specifications
| Size | 50μL/100μL |
| Target | Arnt 2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 79kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARNT2. AA range:21-70 |
| Specificity | Arnt 2 Polyclonal Antibody detects endogenous levels of Arnt 2 protein. |
| Gene Name | ARNT2 |
| Protein Name | Aryl hydrocarbon receptor nuclear translocator 2 |
| Other Name | ARNT2; / BHLHE1; / KIAA0307; / Aryl hydrocarbon receptor nuclear translocator 2; / ARNT protein 2; / Class E basic helix-loop-helix protein 1; / bHLHe1 |
| Species | Human |
| Gene ID | 9915 |
| Uniprot | Q9HBZ2, |
| Species.1 | Mouse |
| Gene ID.1 | 11864 |
| Uniprot.1 | Q61324, |
| Species.2 | Rat |
| Gene ID.2 | 25243 |
| Uniprot.2 | Q78E60 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Brain,Human cervix,Spleen, |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Renal cell carcinoma |
| Research Areas | >>Pathways in cancer; / >>Transcriptional misregulation in cancer; / >>Renal cell carcinoma |
| Function | Function:Specifically recognizes the xenobiotic response element (XRE).,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,similarity:Contains 1 PAC (PAS-associated C-terminal) domain.,similarity:Contains 2 PAS (PER-ARNT-SIM) domains.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Heterodimer with the aryl hydrocarbon receptor (AHR) or the SIM1 protein. Interacts with TACC3., |
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