SKU: WP2227 Categories: ,

BCL7B Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP2227-100
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Product details

Background:

This gene encodes a member of the BCL7 family including BCL7A, BCL7B and BCL7C proteins. This member is BCL7B, which contains a region that is highly similar to the N-terminal segment of BCL7A or BCL7C proteins. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. This gene is located at a chromosomal region commonly deleted in Williams syndrome. This gene is highly conserved from C. elegans to human. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2010],

Specifications

Size50μL/100μL
TargetBCL7B
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)22kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityBCL7B Polyclonal Antibody detects endogenous levels of protein.
Gene NameBCL7B
Protein NameB-cell CLL/lymphoma 7 protein family member B (allergen Hom s 3)
Other Name
SpeciesHuman
Gene ID9275
UniprotQ9BQE9,
Species.1Mouse
Gene ID.1
Uniprot.1Q921K9
Species.2
Gene ID.2
Uniprot.2
Cellular Localization
Tissue ExpressionUbiquitous.
Signaling_pathwayGenetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling
Research Areas
Functionallergen:Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE autoantigen in atopic dermatitis (AD) patients with severe skin manifestations.,Disease:Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,Function:May play a role in lung tumor development or progression.,similarity:Belongs to the BCL7 family.,tissue specificity:Ubiquitous.,
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