BCSC-1 Polyclonal Antibody
Ucallm_WP11270-50
Price range: $268.00 through $328.00
Product details
Background:
VWA5A (von Willebrand factor A domain containing 5A), also known as BCSC-1 (breast cancer suppressor candidate 1) or LOH11CR2A (loss of heterozygosity 11 chromosomal region 2 gene A protein), is a 786 amino acid protein containing one VIT domain and one VWFA domain. VWA5A is expressed at low levels in various tissues, with no expression found in 80% of tumor cell lines. Likely acting as a tumor suppressor gene, deletion of VWA5A leads to loss of heterozygosity (LOH) in breast and ovarian tumors, and may have an important role as a potential gene therapy target. Abnormal expression of VWA5A may lead to an increase in adhesion of CNE-2L2 cells associated with an increase in expression of E-cadherin, alpha-catenin, and p53, resulting in a decrease of malignant activity in cells with ectopic expression of VWA5A. Existing as four alternatively spliced isoforms, the gene encoding VWA5A maps to human chromosome 11q24.2.
Specifications
| Size | 50μL/100μL |
| Target | BCSC-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 86kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human LHR2A. AA range:371-420 |
| Specificity | BCSC-1 Polyclonal Antibody detects endogenous levels of BCSC-1 protein. |
| Gene Name | VWA5A |
| Protein Name | von Willebrand factor A domain-containing protein 5A |
| Other Name | VWA5A; / BCSC1; / LOH11CR2A; / von Willebrand factor A domain-containing protein 5A; / Breast cancer suppressor candidate 1; / BCSC-1; / Loss of heterozygosity 11 chromosomal region 2 gene A protein |
| Species | Human |
| Gene ID | 4013 |
| Uniprot | O00534, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q99KC8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | nucleus,nucleoplasm, |
| Tissue Expression | Expressed at low level in many tissues. Not expressed in 80% of tumor cell lines tested. |
| Signaling_pathway | |
| Research Areas | |
| Function |
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