Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human BTG2
Specificity
This antibody detects endogenous levels of BTG2 at Human, Mouse,Rat
Gene Name
BTG2 PC3
Protein Name
Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3)
Other Name
Species
Human
Gene ID
7832
Uniprot
P78543,
Species.1
Mouse
Gene ID.1
12227
Uniprot.1
Q04211,
Species.2
Rat
Gene ID.2
29619
Uniprot.2
P27049
Cellular Localization
Tissue Expression
Signaling_pathway
Genetic Information Processing >> Folding, sorting and degradation >> RNA degradation
Research Areas
Function
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors (By similarity). Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth.