Price range: $268.00 through $328.00
Background:
Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008],
| Size | 50μL/100μL |
| Target | CD164 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 20kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from CD164 . at AA range: 110-190 |
| Specificity | CD164 Polyclonal Antibody detects endogenous levels of CD164 protein. |
| Gene Name | CD164 |
| Protein Name | Sialomucin core protein 24 |
| Other Name | CD164; / Sialomucin core protein 24; / MUC-24; / Endolyn; / Multi-glycosylated core protein 24; / MGC-24; / MGC-24v; / CD antigen CD164 |
| Species | Human |
| Gene ID | 8763 |
| Uniprot | Q04900, |
| Species.1 | Mouse |
| Gene ID.1 | 53599 |
| Uniprot.1 | Q9R0L9, |
| Species.2 | Rat |
| Gene ID.2 | 83689 |
| Uniprot.2 | Q9QX82 |
| Cellular Localization | Lysosome membrane; Single-pass type I membrane protein . Endosome membrane; Single-pass type I membrane protein . Cell membrane; Single-pass type I membrane protein .; [Isoform 2]: Secreted . |
| Tissue Expression | Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | >>Lysosome |
| Function | Function:This is a carcinoma-associated protein, probably a mucin.,PTM:Highly N- and O-glycosylated; contains sialic acid.,PTM:The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.,similarity:Belongs to the CD164 family.,tissue specificity:Small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma., |
