Name: CD4 [PTR2055] mouse mAb
SKU: WM1259
Price: 268 USD
Availability: InStock

Product details

Background:
CD4 molecule(CD4) Homo sapiens This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],

Specifications

Target	CD4
Reactivity	Human
Applications	WB, IF, ELISA
MW(Calculated)
MW(Observed)	51kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Monoclonal
Clone Number	PTR2055
Immunogen	Synthesized peptide derived from human CD4. AA range: 1-100
Sequence
Specificity	This antibody detects endogenous levels of CD4 protein.
Gene Name	CD4
Protein Name	T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
Other Name	T-cell surface glycoprotein CD4; / T-cell surface antigen T4/Leu-3; / CD antigen CD4
Species	Human
Gene ID-1	920
Uniprot	P01730,
Species.1	Mouse
Gene ID-2	12504
Uniprot.1	P06332,
Species.2	Rat
Gene ID-3	24932
Uniprot.2	P05540
Organism-4
Gene ID-4
SwissProt-4
Background	CD4 molecule(CD4) Homo sapiens This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],
Cellular Localization	Membranous
Tissue Expression	Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Antigen processing and presentation;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction;Environmental Information Processing >> Signaling molecules and interaction >> Cell adhesion molecules
Research Areas
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.; (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 .
RRID

Please login to post questions

CD4 [PTR2055] mouse mAb

Product details

Specifications

About Us

Support

Order

Menu

CD4 [PTR2055] mouse mAb

Product details

Specifications

Related products

U-Blot® Ezrin Rabbit mAb

U-Blot® MMP7 Rabbit mAb

U-Blot® HDAC2 Rabbit mAb

Acetyl Lysine Monoclonal Antibody [10B10]

U-Blot® NLRP3 Rabbit mAb

U-Blot® FOXO3A (Phospho Ser253) Rabbit mAb

Customer Reviews

Menu