Price range: $268.00 through $328.00
Background:
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CD64 |
| Reactivity | Human |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200; ELISA 1:10000-20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthetic peptide from human protein at AA range: 230-280 |
| Specificity | The antibody detects endogenous CD64 |
| Gene Name | FCGR1A FCG1 FCGR1 IGFR1 |
| Protein Name | High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64) |
| Other Name | High affinity immunoglobulin gamma Fc receptor I; / IgG Fc receptor I; / Fc-gamma RI; / FcRI; / Fc-gamma RIA; / FcgammaRIa; / CD antigen CD64 |
| Species | Human |
| Gene ID | 2209 |
| Uniprot | P12314, |
| Species.1 | Mouse |
| Gene ID.1 | 14129 |
| Uniprot.1 | P26151 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein . Stabilized at the cell membrane through interaction with FCER1G. |
| Tissue Expression | Monocyte/macrophage specific. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis;Organismal Systems >> Development and regeneration >> Osteoclast differentiation;Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer;Human Diseases >> Cancer: specific types >> Acute myeloid leukemia;Human Diseases >> Immune disease >> Systemic lupus erythematosus |
| Research Areas | >>Phagosome; / >>Osteoclast differentiation; / >>Neutrophil extracellular trap formation; / >>Hematopoietic cell lineage; / >>Fc gamma R-mediated phagocytosis; / >>Leishmaniasis; / >>Staphylococcus aureus infection; / >>Tuberculosis; / >>Transcriptional misregulation in cancer; / >>Acute myeloid leukemia; / >>Systemic lupus erythematosus |
| Function | Function:High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.,online information:FCGR1A mutation db,PTM:N-glycosylated.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the immunoglobulin superfamily. FCGR1 family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Stabilized at the cell membrane through interaction with FCER1G.,subunit:Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL.,tissue specificity:Monocyte/macrophage specific., |
