Price range: $268.00 through $328.00
Background:
function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production., PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist., similarity:Belongs to the G-protein coupled receptor 1 family.,
| Size | 50μL/100μL |
| Target | CD88 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human N ternal CD88/C5aR. AA range:301-350 |
| Specificity | CD88 Polyclonal Antibody detects endogenous levels of CD88 protein. |
| Gene Name | C5AR1 |
| Protein Name | C5a anaphylatoxin chemotactic receptor |
| Other Name | C5AR1; / C5AR; / C5R1; / C5a anaphylatoxin chemotactic receptor; / C5a-R; / C5aR; / CD antigen CD88 |
| Species | Human |
| Gene ID | 728 |
| Uniprot | P21730, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P30993 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Cytoplasmic vesicle . Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. . |
| Tissue Expression | Brain, |
| Signaling_pathway | Organismal Systems >> Immune system >> Complement and coagulation cascades;Organismal Systems >> Immune system >> Neutrophil extracellular trap formation |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Complement and coagulation cascades; / >>Neutrophil extracellular trap formation; / >>Alcoholic liver disease; / >>Staphylococcus aureus infection; / >>Coronavirus disease - COVID-19 |
| Function | Function:Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.,PTM:Sulfation plays a critical role in the association of the receptor with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small peptide agonist.,similarity:Belongs to the G-protein coupled receptor 1 family., |
