Price range: $268.00 through $328.00
Background:
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | CNK1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 80kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human CNKR1. AA range:491-540 |
| Specificity | CNK1 Polyclonal Antibody detects endogenous levels of CNK1 protein. |
| Gene Name | CNKSR1 |
| Protein Name | Connector enhancer of kinase suppressor of ras 1 |
| Other Name | CNKSR1; / CNK1; / Connector enhancer of kinase suppressor of ras 1; / Connector enhancer of KSR 1; / CNK homolog protein 1; / CNK1; / hCNK1; / Connector enhancer of KSR-like |
| Species | Human |
| Gene ID | 10256 |
| Uniprot | Q969H4 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Membrane; Peripheral membrane protein . |
| Tissue Expression | Brain,Epithelium,Kidney,Liver,Neuroepithelium,Place |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May function as an adapter protein or regulator of Ras signaling pathways.,PTM:Phosphorylated on tyrosine.,similarity:Belongs to the CNKSR family.,similarity:Contains 1 CRIC domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,subunit:Interacts with RHO and RALGDS., |
