Name: Cox-1 Polyclonal Antibody
SKU: WP11762
Price: 268 USD
Availability: InStock

Cox-1 Polyclonal Antibody

Ucallm_WP11762-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP11762-100

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Product details

Background:

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],

Specifications

Size	50μL/100μL
Target	COX1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	70kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human Cox1. AA range:550-599
Specificity	Cox-1 Polyclonal Antibody detects endogenous levels of Cox-1 protein.
Gene Name	PTGS1
Protein Name	Prostaglandin G/H synthase 1
Other Name	PTGS1; / COX1; / Prostaglandin G/H synthase 1; / Cyclooxygenase-1; / COX-1; / Prostaglandin H2 synthase 1; / PGH synthase 1; / PGHS-1; / PHS 1; / Prostaglandin-endoperoxide synthase 1
Species	Human
Gene ID	5742
Uniprot	P23219,
Species.1	Mouse
Gene ID.1	19224
Uniprot.1	P22437,
Species.2	Rat
Gene ID.2	24693
Uniprot.2	Q63921
Cellular Localization	Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Tissue Expression	Brain,Lung fibroblast,Platelet,
Signaling_pathway	Organismal Systems >> Immune system >> Platelet activation
Research Areas	>>Arachidonic acid metabolism; / >>Metabolic pathways; / >>Platelet activation; / >>Serotonergic synapse; / >>Regulation of lipolysis in adipocytes
Function	Catalytic activity:Arachidonate + AH(2) + 2 O(2) = prostaglandin H(2) + A + H(2)O.,cofactor:Binds 1 heme B (iron-protoporphyrin IX) group per subunit.,Function:May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.,miscellaneous:This enzyme acts both as a dioxygenase and as a peroxidase.,miscellaneous:This enzyme is the target of nonsteroidal anti-inflammatory drugs such as aspirin.,pathway:Lipid metabolism; prostaglandin biosynthesis.,similarity:Belongs to the prostaglandin G/H synthase family.,similarity:Contains 1 EGF-like domain.,subunit:Homodimer.,