Name: CyPA Polyclonal Antibody
SKU: WP15273
Price: 268 USD
Availability: InStock

CyPA Polyclonal Antibody

Ucallm_WP15273-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WP15273-100

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Product details

Background:

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	CYPA
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	18kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC: 1:100-300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from the Internal region of human PPIA. AA range:51-100
Specificity	CyPA Polyclonal Antibody detects endogenous levels of CyPA protein.
Gene Name	PPIA
Protein Name	Peptidyl-prolyl cis-trans isomerase A
Other Name	PPIA; / CYPA; / Peptidyl-prolyl cis-trans isomerase A; / PPIase A; / Cyclophilin A; / Cyclosporin A-binding protein; / Rotamase A
Species	Human
Gene ID	5478
Uniprot	P62937,
Species.1	Mouse
Gene ID.1	268373
Uniprot.1	P17742,
Species.2	Rat
Gene ID.2	100360977
Uniprot.2	P10111
Cellular Localization	Cytoplasm . Secreted . Nucleus . Secretion occurs in response to oxidative stress in vascular smooth muscle through a vesicular secretory pathway that includes Rho GTPase signaling, actin remodeling, and myosin II activation. .
Tissue Expression	Blood,Bone marrow,Brain,Cajal-Retzius cell,Cervix,Colon,Epithelium,Fetal br
Signaling_pathway	Cellular Processes >> Cell growth and death >> Necroptosis
Research Areas	>>Viral life cycle - HIV-1; / >>Necroptosis
Function	Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,enzyme regulation:Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase.,Function:PPIases accelerate the folding of proteins.,Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,online information:Cyclophilin entry,similarity:Belongs to the cyclophilin-type PPIase family.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subunit:Interacts with HIV-1 Capsid protein.,