SKU: WP7237 Categories: ,

DNASE2 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP7237-100
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Product details

Background:

Specifications

Size50μL/100μL
TargetDNASE2
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)40kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human DNASE2
SpecificityThis antibody detects endogenous levels of DNASE2 at Human, Mouse,Rat
Gene NameDNASE2 DNASE2A DNL2
Protein NameDeoxyribonuclease-2-alpha (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)
Other Name
SpeciesHuman
Gene ID1777
UniprotO00115,
Species.1Mouse
Gene ID.113423
Uniprot.1P56542,
Species.2Rat
Gene ID.2171575
Uniprot.2Q9QZK8
Cellular LocalizationLysosome.
Tissue Expression
Signaling_pathwayCellular Processes >> Transport and catabolism >> Lysosome;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Research Areas
FunctionHydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
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