Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human DNASE2
Specificity
This antibody detects endogenous levels of DNASE2 at Human, Mouse,Rat
Gene Name
DNASE2 DNASE2A DNL2
Protein Name
Deoxyribonuclease-2-alpha (Acid DNase) (Deoxyribonuclease II alpha) (DNase II alpha) (Lysosomal DNase II) (R31240_2)
Other Name
Species
Human
Gene ID
1777
Uniprot
O00115,
Species.1
Mouse
Gene ID.1
13423
Uniprot.1
P56542,
Species.2
Rat
Gene ID.2
171575
Uniprot.2
Q9QZK8
Cellular Localization
Lysosome.
Tissue Expression
Signaling_pathway
Cellular Processes >> Transport and catabolism >> Lysosome;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway
Research Areas
Function
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.