SKU: WP12193 Categories: ,

EP3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12193-100
Enter the quantity you would like, or drag the panel to find the quantity and price that best for you
Bulk QuoteAuthorize OEM & ODM

Product details

Background:

The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009],

Specifications

Size50μL/100μL
TargetEP3
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)
MW(Observed)43kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human PTGER3. AA range:16-65
SpecificityEP3 Polyclonal Antibody detects endogenous levels of EP3 protein.
Gene NamePTGER3
Protein NameProstaglandin E2 receptor EP3 subtype
Other NamePTGER3; / Prostaglandin E2 receptor EP3 subtype; / PGE receptor EP3 subtype; / PGE2 receptor EP3 subtype; / PGE2-R; / Prostanoid EP3 receptor
SpeciesHuman
Gene ID5733
UniprotP43115,
Species.1Mouse
Gene ID.1
Uniprot.1P30557
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCell membrane; Multi-pass membrane protein .
Tissue ExpressionDetected in kidney (PubMed:8117308, PubMed:8135729). Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.
Signaling_pathwayHuman Diseases >> Cancer: overview >> Pathways in cancer;Environmental Information Processing >> Signal transduction >> Calcium signaling pathway;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas>>Calcium signaling pathway; / >>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Regulation of lipolysis in adipocytes; / >>Human cytomegalovirus infection; / >>Pathways in cancer
FunctionAlternative products:Additional isoforms seem to exist,Function:Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels.,
Please login to post questions
Back to Top
Product has been added to your cart