SKU: WP12202 Categories: ,

EphA3 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP12202-100
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Product details

Background:

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetEphA3
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)100kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from EphA3 . at AA range: 540-620
SpecificityEphA3 Polyclonal Antibody detects endogenous levels of EphA3 protein.
Gene NameEPHA3 ETK ETK1 HEK TYRO4
Protein NameEphrin type-A receptor 3
Other NameEPHA3; / ETK; / ETK1; / HEK; / TYRO4; / Ephrin type-A receptor 3; / EPH-like kinase 4; / EK4; / hEK4; / HEK; / Human embryo kinase; / Tyrosine-protein kinase TYRO4; / Tyrosine-protein kinase receptor ETK1; / Eph-like tyrosine kinase 1
SpeciesHuman
Gene ID2042
UniprotP29320,
Species.1Mouse
Gene ID.1
Uniprot.1P29319,
Species.2Rat
Gene ID.229210
Uniprot.2O08680
Cellular Localization[Isoform 1]: Cell membrane; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Tissue ExpressionWidely expressed. Highest level in placenta.
Signaling_pathway
Research Areas>>Axon guidance
FunctionCatalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,Disease:Defects in EPHA3 may be a cause of colorectal cancer (CRC) [MIM:114500].,Function:Receptor for members of the ephrin-A family. Binds to ephrin-A2, -A3, -A4 and -A5. Could play a role in lymphoid function.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Widely expressed. Highest level in placenta.,
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