Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
| Size | 50μL/100μL |
| Target | Fyb |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from Fyb . at AA range: 620-700 |
| Specificity | Fyb Polyclonal Antibody detects endogenous levels of Fyb protein. |
| Gene Name | FYB |
| Protein Name | FYN-binding protein |
| Other Name | FYB; / SLAP130; / FYN-binding protein; / Adhesion and degranulation promoting adaptor protein; / ADAP; / FYB-120/130; / p120/p130; / FYN-T-binding protein; / SLAP-130; / SLP-76-associated phosphoprotein |
| Species | Human |
| Gene ID | 2533 |
| Uniprot | O15117, |
| Species.1 | Mouse |
| Gene ID.1 | 23880 |
| Uniprot.1 | O35601 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Cell junction . Colocalizes with TMEM47 at cell-cell contacts in podocytes. . |
| Tissue Expression | Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Rap1 signaling pathway |
| Research Areas | >>Rap1 signaling pathway; / >>Yersinia infection |
| Function | Function:Acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.,PTM:T-cell receptor ligation leads to increased tyrosine phosphorylation.,similarity:Contains 1 SH3 domain.,subunit:Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2.,tissue specificity:Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues., |
