Price range: $268.00 through $328.00
Background:
Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | CBY1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 14kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CBY1 AA range: 71-121 |
| Specificity | This antibody detects endogenous levels of CBY1 at Human/Mouse/Rat |
| Gene Name | CBY1 ARB1 C22orf2 CBY PGEA1 HRIHFB2025 |
| Protein Name | CBY1 |
| Other Name | |
| Species | Human |
| Gene ID | 25776 |
| Uniprot | Q9Y3M2, |
| Species.1 | Mouse |
| Gene ID.1 | 73739 |
| Uniprot.1 | Q9D1C2, |
| Species.2 | Rat |
| Gene ID.2 | 246768 |
| Uniprot.2 | Q8K4I6 |
| Cellular Localization | Nucleus speckle . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Golgi apparatus. Golgi apparatus, trans-Golgi network . |
| Tissue Expression | Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Wnt signaling pathway |
| Research Areas | >>Wnt signaling pathway |
| Function | Function:Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation.,miscellaneous:Chibby is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.,similarity:Belongs to the chibby family.,subcellular location:Nuclear, in a punctate manner. Also found in the trans-Golgi.,subunit:Homodimer; interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin.,tissue specificity:Widely expressed. Expressed at higher levels in heart, skeletal muscle, kidney and placenta. Also found in brain, lung, liver and testis. Significantly down-regulated in thyroid and metastatic uterine tumors., |
