GDF1 Polyclonal Antibody
Ucallm_WP3269-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. The encoded protein is translated from a bicistronic mRNA that also encodes ceramide synthase 1. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Jul 2016],
Specifications
| Size | 50μL/100μL |
| Target | GDF1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 321-370 |
| Specificity | GDF1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | GDF1 |
| Protein Name | Embryonic growth/differentiation factor 1 (GDF-1) |
| Other Name | |
| Species | Human |
| Gene ID | 2657 |
| Uniprot | P27539, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P20863 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed in the brain. |
| Signaling_pathway | Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction |
| Function | Function:May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner.,Function:May mediate cell differentiation events during embryonic development.,miscellaneous:This protein is produced by a bicistronic gene which also produces the GDF1 protein from a non-overlapping reading frame.,miscellaneous:This protein is produced by a bicistronic gene which also produces the LASS1 protein from a non-overlapping reading frame.,similarity:Belongs to the TGF-beta family.,similarity:Contains 1 TLC (TRAM/LAG1/CLN8) domain.,subcellular location:Isoform 1 may recycle from the Golgi to the endoplasmic reticulum.,subunit:Homodimer; disulfide-linked.,tissue specificity:Expressed in the brain., |
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