Price range: $268.00 through $328.00
Background:
This gene encodes a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | IFNK |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 70-150 |
| Specificity | IFNK Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | IFNK UNQ6124/PRO20084 |
| Protein Name | Interferon kappa (IFN-kappa) |
| Other Name | |
| Species | Human |
| Gene ID | 56832 |
| Uniprot | Q9P0W0, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q7TSL0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted. |
| Tissue Expression | Expressed in keratinocytes, monocytes and in resting dendritic cells. |
| Signaling_pathway | Organismal Systems >> Immune system >> RIG-I-like receptor signaling pathway;Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway;Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction |
| Research Areas | >>Cytokine-cytokine receptor interaction; / >>RIG-I-like receptor signaling pathway; / >>JAK-STAT signaling pathway |
| Function | Function:May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin.,induction:By viral infection, upon exposure to double-stranded RNA, or upon treatment with either interferon-gamma or interferon-beta.,similarity:Belongs to the alpha/beta interferon family.,tissue specificity:Expressed in keratinocytes, monocytes and in resting dendritic cells., |
