Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
Clonality
Polyclonal
Clone Number
Immunogen
Synthesized peptide derived from human IMPCT AA range: 123-173
Specificity
This antibody detects endogenous levels of IMPCT at Human/Mouse/Rat
Gene Name
IMPACT
Protein Name
IMPCT
Other Name
Species
Human
Gene ID
55364
Uniprot
Q9P2X3,
Species.1
Mouse
Gene ID.1
16210
Uniprot.1
O55091,
Species.2
Rat
Gene ID.2
497198
Uniprot.2
Q5GFD9
Cellular Localization
Cytoplasm .
Tissue Expression
Widely expressed. Expressed at high level in brain.
Signaling_pathway
Research Areas
Function
Function:Translational regulator that ensures constant high levels of translation under amino acid starvation. Acts by interacting with GCN1/GCN1L1, thereby preventing activation of GCN2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis.,miscellaneous:In contrast to the mouse or rabbit ortholog, the IMPACT locus is not imprinted in human.,similarity:Belongs to the IMPACT family.,similarity:Contains 1 RWD domain.,subunit:Interacts with GCN1/GCN1L1.,tissue specificity:Widely expressed. Expressed at high level in brain.,